I have just used a road-warrior connection with SSL/TLS+User Auth to both a 2.1.5 and a 2.2.2 system. So it does work. I am using OpenVPN Manager on Windows 7 and config produced by the OpenVPN Client Export package. For me, it "just works".
TLS key negotiation failed to occur within 60 seconds (check your network connectivity)
That message usually means the client is simply not reaching the server - FQDN used by the client does not resolve to the proper server IP, server is not listening on the port…
Post your server settings, what client you are using, how you installed on the client.