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You can just update, the patches are a part of 21.02.2/2.1.5.
Alternately, you can remove the patch entries (Do NOT revert, just delete them) either before or after upgrade and leave the patches package in place.
The only possible action you might need to take is to make sure none of them are set to auto-apply. In most cases that wouldn't hurt anything since it would just fail to apply, but certain diffs may end up adding themselves multiple times that way.
