• When ntpd is starting up it seems to try and listen on all interfaces, and both IPv4 and IPv6. In my example system there is no IPv6 and it logs a whole bunch of "fails: Can't assign requested address" messages.
    It does no harm, but is just noise in the log, and the word "fail" can make users think there is a problem.
    Probably do not care - but if it is easy to fix then why not.

    Sample ntpd log:

    Nov 28 08:03:34 	ntpd[60859]: Listening on routing socket on fd #48 for interface updates
    Nov 28 08:03:34 	ntpd[60859]: Listen normally on 27 ovpnc2 10.49.239.2:123
    Nov 28 08:03:34 	ntpd[60859]: setsockopt IPV6_MULTICAST_IF 0 for fe80::20d:b9ff:fe24:59c0%18 fails: Can't assign requested address
    Nov 28 08:03:34 	ntpd[60859]: Listen normally on 26 ovpnc2 [fe80::20d:b9ff:fe24:59c0%18]:123
    Nov 28 08:03:34 	ntpd[60859]: Listen normally on 25 gif0 [fe80::20d:b9ff:fe24:59c0%16]:123
    Nov 28 08:03:34 	ntpd[60859]: Listen normally on 24 gif0 [2001:470:35:a7c::2]:123
    Nov 28 08:03:34 	ntpd[60859]: Listen normally on 23 vr0_vlan70 10.11.70.250:123
    Nov 28 08:03:34 	ntpd[60859]: setsockopt IPV6_MULTICAST_IF 0 for fe80::20d:b9ff:fe24:59c0%15 fails: Can't assign requested address
    Nov 28 08:03:34 	ntpd[60859]: Listen normally on 22 vr0_vlan70 [fe80::20d:b9ff:fe24:59c0%15]:123
    Nov 28 08:03:34 	ntpd[60859]: Listen normally on 21 vr0_vlan60 10.11.60.250:123
    Nov 28 08:03:34 	ntpd[60859]: setsockopt IPV6_MULTICAST_IF 0 for fe80::20d:b9ff:fe24:59c0%14 fails: Can't assign requested address
    Nov 28 08:03:34 	ntpd[60859]: Listen normally on 20 vr0_vlan60 [fe80::20d:b9ff:fe24:59c0%14]:123
    Nov 28 08:03:34 	ntpd[60859]: Listen normally on 19 vr0_vlan50 10.11.50.250:123
    Nov 28 08:03:34 	ntpd[60859]: setsockopt IPV6_MULTICAST_IF 0 for fe80::20d:b9ff:fe24:59c0%13 fails: Can't assign requested address
    Nov 28 08:03:34 	ntpd[60859]: Listen normally on 18 vr0_vlan50 [fe80::20d:b9ff:fe24:59c0%13]:123
    Nov 28 08:03:34 	ntpd[60859]: Listen normally on 17 vr0_vlan40 10.11.40.250:123
    Nov 28 08:03:34 	ntpd[60859]: setsockopt IPV6_MULTICAST_IF 0 for fe80::20d:b9ff:fe24:59c0%12 fails: Can't assign requested address
    Nov 28 08:03:34 	ntpd[60859]: Listen normally on 16 vr0_vlan40 [fe80::20d:b9ff:fe24:59c0%12]:123
    Nov 28 08:03:34 	ntpd[60859]: Listen normally on 15 vr0_vlan30 10.11.30.250:123
    Nov 28 08:03:34 	ntpd[60859]: setsockopt IPV6_MULTICAST_IF 0 for fe80::20d:b9ff:fe24:59c0%11 fails: Can't assign requested address
    Nov 28 08:03:34 	ntpd[60859]: Listen normally on 14 vr0_vlan30 [fe80::20d:b9ff:fe24:59c0%11]:123
    Nov 28 08:03:34 	ntpd[60859]: Listen normally on 13 vr0_vlan20 10.11.20.250:123
    Nov 28 08:03:34 	ntpd[60859]: setsockopt IPV6_MULTICAST_IF 0 for fe80::20d:b9ff:fe24:59c0%10 fails: Can't assign requested address
    Nov 28 08:03:34 	ntpd[60859]: Listen normally on 12 vr0_vlan20 [fe80::20d:b9ff:fe24:59c0%10]:123
    Nov 28 08:03:34 	ntpd[60859]: Listen normally on 11 ath0_wlan0 10.49.212.250:123
    Nov 28 08:03:34 	ntpd[60859]: setsockopt IPV6_MULTICAST_IF 0 for fe80::6202:b4ff:fe0c:4539%9 fails: Can't assign requested address
    Nov 28 08:03:34 	ntpd[60859]: Listen normally on 10 ath0_wlan0 [fe80::6202:b4ff:fe0c:4539%9]:123
    Nov 28 08:03:34 	ntpd[60859]: setsockopt IPV6_MULTICAST_IF 0 for fe80::1%7 fails: Can't assign requested address
    Nov 28 08:03:34 	ntpd[60859]: Listen normally on 9 lo0 [fe80::1%7]:123
    Nov 28 08:03:34 	ntpd[60859]: Listen normally on 8 lo0 [::1]:123
    Nov 28 08:03:34 	ntpd[60859]: Listen normally on 7 lo0 127.0.0.1:123
    Nov 28 08:03:34 	ntpd[60859]: Listen normally on 6 vr2 192.168.2.200:123
    Nov 28 08:03:34 	ntpd[60859]: setsockopt IPV6_MULTICAST_IF 0 for fe80::20d:b9ff:fe24:59c2%3 fails: Can't assign requested address
    Nov 28 08:03:34 	ntpd[60859]: Listen normally on 5 vr2 [fe80::20d:b9ff:fe24:59c2%3]:123
    Nov 28 08:03:34 	ntpd[60859]: setsockopt IPV6_MULTICAST_IF 0 for fe80::20d:b9ff:fe24:59c1%2 fails: Can't assign requested address
    Nov 28 08:03:34 	ntpd[60859]: Listen normally on 4 vr1 [fe80::20d:b9ff:fe24:59c1%2]:123
    Nov 28 08:03:34 	ntpd[60859]: Listen normally on 3 vr0 10.49.208.250:123
    Nov 28 08:03:34 	ntpd[60859]: setsockopt IPV6_MULTICAST_IF 0 for fe80::20d:b9ff:fe24:59c0%1 fails: Can't assign requested address
    Nov 28 08:03:34 	ntpd[60859]: Listen normally on 2 vr0 [fe80::20d:b9ff:fe24:59c0%1]:123
    Nov 28 08:03:34 	ntpd[60859]: Listen and drop on 1 v4wildcard 0.0.0.0:123
    Nov 28 08:03:34 	ntpd[60859]: Listen and drop on 0 v6wildcard [::]:123
    Nov 28 08:03:34 	ntpd[60859]: proto: precision = 2.328 usec (-19)
    Nov 28 08:03:34 	ntpd[60675]: Command line: /usr/local/sbin/ntpd -g -c /var/etc/ntpd.conf -p /var/run/ntpd.pid
    Nov 28 08:03:33 	ntpd[60675]: ntpd 4.2.7p479@1.2483-o Tue Nov 18 19:58:26 UTC 2014 (1): Starting
    Nov 28 08:03:33 	ntp: Starting NTP Daemon.
    Nov 28 08:03:33 	ntp: Successfully synced time after 1 attempts.
    Nov 28 08:03:33 	ntpdate[49749]: adjust time server 50.31.240.56 offset -0.124433 sec