Hi Mats - I've managed to get a bit further. I decided to start from fresh.
I created 3 backends like so:-
ACME
active localacmeserv Address+Port: 192.168.50.10 8126 no
WebServers
active THEMIS Address+Port: 192.168.50.189 80 no
WebServers2
active GLAUCUS Address+Port: 192.168.50.185 80 no
I created 4 Frontends :-
HTTP-Edge
Any (IPv4) 80
Any (IPv6) 80
Any (IPv4) 443
Any (IPv6) 443
Use "forwardfor" option - Ticked (Wasn't sure if this is needed or not)
WebServers
Shared Frontend option - ticked
Primary frontend - HTTP-Edge
ACL1 Host matches: no www.mywebsite.co.uk
Actions
Use Backend See below ACL1
Use backend WebServers
I then cloned this frontend an setup an ACL for my second website to the Webservers2 backend. This all seems to work.
I created a final frontend for ACME like so:-
ACMEFrontend
Shared front end - ticked
Front end - HTTP-Edge
acme Path starts with: yes /.well-known/acme-challenge
Use Backend See below acme
Backend points to ACME backend.
Attempt to renew Exchange 2013 SAN certificate which has
enabled mail.mydomain.co.uk standalone HTTP server
Port 8126
Enabled autodiscover.mydomain.co.uk standalone HTTP server
Port 8126
[Fri Jul 7 00:20:11 BST 2017] Standalone mode.
[Fri Jul 7 00:20:12 BST 2017] Standalone mode.
[Fri Jul 7 00:20:12 BST 2017] Multi domain='DNS:autodiscover.mydomain.co.uk'
[Fri Jul 7 00:20:12 BST 2017] Getting domain auth token for each domain
[Fri Jul 7 00:20:12 BST 2017] Getting webroot for domain='mail.mydomain.co.uk'
[Fri Jul 7 00:20:12 BST 2017] Getting new-authz for domain='mail.mydomain.co.uk'
[Fri Jul 7 00:20:28 BST 2017] The new-authz request is ok.
[Fri Jul 7 00:20:28 BST 2017] Getting webroot for domain='autodiscover.mydomain.co.uk'
[Fri Jul 7 00:20:28 BST 2017] Getting new-authz for domain='autodiscover.mydomain.co.uk'
[Fri Jul 7 00:20:30 BST 2017] The new-authz request is ok.
[Fri Jul 7 00:20:30 BST 2017] mail.mydomain.co.uk is already verified, skip http-01.
[Fri Jul 7 00:20:30 BST 2017] Verifying:autodiscover.mydomain.co.uk
[Fri Jul 7 00:20:30 BST 2017] Standalone mode server
[Fri Jul 7 00:20:36 BST 2017] autodiscover.mydomain.co.uk:Verify error:Invalid response from http://autodiscover.mydomain.co.uk/.well-known/acme-challenge/-G-QfC3FZa66VzIHB2rvanHig3CqBxJPONFSdO0QxLs
The Exchange 2013 server is running behind the firewall.
Any ideas? - This is hurting my brain!