@bsd3000:
Probably I need to upgrade my hardware (I read all document about tunning)
So, instead of my hp DL360 server with embedded 2xBroadcom, what hardware do you recommend?
Integrated Intel or PCI-E addonn card?
What the best Nic? (model/chipset)
AMD 16x core Proc or Intel Quad Core Xeon?
You can throw some more hardware at the problem in the hope it might make a difference but you really need to get more information on what was going on in order to correctly determine the solution. For example, if you have a rogue system (or systems) issuing floods of DNS requests it is unlikely that adding more cores or "server quality" NICs or more RAM will allow you to give "good" DNS response to other systems.