Having the same trouble. After upgrading, the second re1 stopped working as soon as bsd loaded. I tried re-installing, but formatting re-installing didn't help because pfsense downloaded the latest version which disabled the second nic, again!. ifup re1 didn't work. I could see that I had a physical link, until bsd loaded and before the firewall software loaded up. The problem appears to be BSD and not pfsense. I can't install packages because 2.4.3 is looking for an upgrade and, frankly, I really don't want suffer the same trouble on a production system. Any help here would be appreciated. Not the way I wanted to spend my saturday afternoon.
I ended up installing on a completely different system.
Thanks