Yes.
Fairly advanced OpenVPN concept though.
You have to assign an interface to the OpenVPN client instance at Site A and be sure that the port-forwarded traffic does not match the firewall rules on the Site A side's OpenVPN tab and only matches a firewall rule on the assigned interface tab at Site A. This gets reply-to working there preventing the reply traffic from the port-forward target host from being routed out the default gateway at Site A and routing back through the tunnel instead.
I am not certain this specific use case was covered but you might do well to watch this:
https://www.youtube.com/watch?v=ku-fNfJJV7w