Well this sort of worked. The interface was sitting quite happily at 1500mtu and I tested that I could ping without fragmentation:
C:\Users\Administrator>ping -f -l 1472 github.com
Pinging github.com [192.30.253.112] with 1472 bytes of data:
Reply from 192.30.253.112: bytes=1472 time=86ms TTL=56
Reply from 192.30.253.112: bytes=1472 time=86ms TTL=56
Reply from 192.30.253.112: bytes=1472 time=87ms TTL=56
Reply from 192.30.253.112: bytes=1472 time=87ms TTL=56
Ping statistics for 192.30.253.112:
Packets: Sent = 4, Received = 4, Lost = 0 (0% loss),
Approximate round trip times in milli-seconds:
Minimum = 86ms, Maximum = 87ms, Average = 86ms
Which worked fine. But now this morning, it's back to 1492 and fragmenting again.
One thing I did notice when it was working ok was that my WAN interface didn't appear to have an IPv6 address, but now it does. IPv6 was still working without it though.